Electronic Theses and Dissertation

ABSTRAK
Latar Belakang : Meningioma merupakan tumor sistem saraf pusat (SSP) yang paling umum dan sering ditemukan klinis yang baik. Terkait faktor resiko hormonal, terdapat laporan bahwa ekspresi reseptor estrogen, progesteron dan androgen ditemukan pada sekitar dua pertiga pasien dengan riwayat kontrasepsi. Beberapa penelitian telah mengeksplorasi kemungkinan hubungan antara terapi penggantian hormon atau penggunaan kontrasepsi oral dan risiko meningioma. Di Aceh sendiri penelitian tentang pengaruh langsung kontrasepsi hormonal terhadap progresifitas tumor meningioma masih belum ada.
Tujuan : Mengetahui hubungan kontrasepsi hormonal terhadap meningioma pada wanita di Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh.
Metode : Sebanyak 34 pasien yang memenuhi kriteria inklusi dan ekslusi dimasukkan kedalam penelitian ini. Penelitian ini menggunakan metodologi analitik crosssectional dengan pendekatan kohort retrospektif. Data meningioma pasien diambil dari data klinis, radiologis, dan histopatologi dan telah ditetapkan diagnosa menigioma oleh dokter spesialis. Kemudian data riwayat kontrasepsi pasien diperoleh melalui wawancara.
Hasil : Berdasarkan uji statistik menggunakan uji binomial didapatkan hubungan yang signifikan antara kejadian meningioma dengan riwayat kontrasepsi (p

ABSTRACT Background: Meningioma is the most common central nervous system (SSP) tumor and is often found clinically. Regarding hormonal risk factors, there are reports that the expression of estrogen receptors, progesterone and androgens are found in about two-thirds of patients with a history of contraception. Some studies have explored possible relationships between hormone replacement therapy or oral contraceptives with the risk of meningioma. In Aceh itself, research on direct influence of hormonal contraception to the progressiveness of meningioma tumors still does not exist. Objective: To determine relationship between hormonal contraceptives of meningioma in women at the General Hospital Dr. Zainoel Abidin Banda Aceh. Method: A total of 34 patients who met the inclusion and exclusion criteria and 34 control group patients were included in this research. This study uses crosssectional analytic methodology with a retrospective cohort approach. Data meningioma patients were taken from clinical, radiological, and histopathological data and had been determined by a diagnosis of tending by a specialist. Then the patient's contraceptive history data obtained through interviews. Results: Based on statistical tests using the binomial test, there was a significant relationship between the incidence of meningioma and history of contraception (p