Electronic Theses and Dissertation

Abstrak pendahuluan: preeklampsia termasuk permasalahan kesehatan global yang menjadi penyebab umum mortalitas ibu selama dan pasca kehamilan. wanita hamil cenderung mengalami defisiensi nutrisi termasuk zinc. zinc merupakan substrat esensial yang berperan penting pada fisiologi tubuh utamanya selama kehamilan. penelitian ini bertujuan untuk menilai perbandingan kadar zinc serum pada penderita preeklampsia dan kehamilan normal metode: penelitian ini termasuk studi observasional dengan desain potong lintang. wanita hamil yang memenuhi kriteria penelitian, kehamilan normal dan preeklampsia akan dijadikan subjek penelitian dan dilakukan pengukuran terhadap kadar zinc serum dengan metode icpms. penelitian ini menggunakan analisis independent sample t-test dengan tingkat kepercayaan 95%. hasil: sebanyak 52 subjek terlibat dalam penelitian ini dengan rerata usia wanita kehamilan normal dan preeklampsia secara berurutan adalah 31,62 dan 32,37 tahun. rerata kadar zinc pada kehamilan normal adalah 51,46 µg/dl dan preeklamsi sebesar 35,96 µg/dl. terdapat perbedaan kadar zinc yang lebih rendah pada preeklampsia sebesar 15,5 µg/dl (p < 0,001) dibandingkan dengan kehamilan normal. kesimpulan: kadar zinc serum penderita preeklamasi lebih rendah dibandingkan dengan kehamilan normal. kata kunci: preeklampsia, kadar zinc, kehamilan

ABSTRACT Introduction: Preeclampsia is a global health problem and a common cause of maternal mortality during and after pregnancy. Pregnant women tend to have nutritional deficiencies including zinc. Zinc is an essential substrate that plays an important role in the physiology of the body, especially during pregnancy. This study aims to assess the comparison of serum zinc levels in patients with preeclampsia and normal pregnancy Method: This study is an observational study with a cross-sectional design. Pregnant women who met the study criteria, normal pregnancy and preeclampsia will be included as research subjects and will be measured on serum zinc levels used the ICPMS method. This study used an independent sample t-test analysis with a 95% confidence level. Result: A total of 52 subjects were involved in this study with the mean age of women with normal pregnancy and preeclampsia respectively being 31.62 and 32.37 years. The average zinc level in normal pregnancy is 51.46 g/dL and preeclampsia is 35.96 g/dL. There was a difference in zinc levels lower in preeclampsia by 15.5 g/dL (p < 0.001) compared to normal pregnancy. Conclusion: Zinc serum levels in patients with preeclampsia are lower than normal pregnancies. Keywords: Preeclampsia, zinc levels, pregnancy