Electronic Theses and Dissertation

Plumbum poisoning has become a public health problem in the world. vitamin e is an antioxidant compound that allergedly reduces cytotoxity plumbum. the purpose of this study was to determine the effect of vitamin e in mice exposed plumbum. this study is a laboratory experimental research which used a complete random design. in this study, vitamin e was given orally everyday for 7 days. then plumbum was given intraperitoneally two hours after vitamin e. examination of urea and creatinine was done 2 days after. there were 5 groups in this research, such as: group i (aquadest), group ii (20 mg /kgbw plumbum), group iii (200 mg / kgbw vitamin e + 20 mg / kgbw plumbum), group iv (500 mg / kgbw vitamin e + 20 mg / kgbw plumbum), group v (1000 mg / kgbw vitamin e + 20 mg / kgbw plumbum). the results of this study indicated that there is no significant effect of vitamin e protection against plumbum. this may be caused by a lack of high doses of vitamin e that was given so that the protection that caused was less effective. the conclusion of this study is vitamin e does not provide effective protection against plumbum exposure. keywords : plumbum, vitamin e, urea and creatine