Electronic Theses and Dissertation

Penggunaan steroid kronik dapat menyebabkan supresi aksis hipotalamus–pituitari–adrenal yang berujung pada insufisiensi adrenal serta memengaruhi berbagai aspek metabolisme, termasuk metabolisme lipid. hubungan antara kadar kortisol dan trigliserida pada pengguna steroid kronik masih belum sepenuhnya dipahami, khususnya pada pasien dengan risiko insufisiensi adrenal. penelitian ini bertujuan untuk menganalisis hubungan antara kadar trigliserida dan kadar kortisol serum pada pengguna steroid kronik dengan risiko insufisiensi adrenal. penelitian observasional analitik dengan desain potong lintang ini dilakukan pada 53 pasien pengguna steroid kronik di poliklinik penyakit dalam rsud dr. zainoel abidin banda aceh. sampel diperoleh dengan metode consecutive sampling sesuai kriteria inklusi dan eksklusi. kadar kortisol serum diperiksa menggunakan metode elisa, sedangkan kadar trigliserida diperiksa dengan metode enzimatik kolorimetri. analisis hubungan dilakukan menggunakan uji korelasi spearman dan dilanjutkan dengan regresi linear multivariat. analisis korelasi spearman menunjukkan hubungan negatif yang signifikan antara kadar kortisol serum dan trigliserida (r=-0,302; p=0,024). setiap peningkatan kadar trigliserida 1 mg/dl berhubungan dengan penurunan kadar kortisol serum sebesar 0,019 μg/dl (β=-0,019; p=0,025). namun, pada analisis regresi linear multivariat, kadar trigliserida tidak berhubungan secara independen dengan kadar kortisol serum (β=-0,002; p=0,394). faktor yang berhubungan signifikan dengan kadar kortisol serum adalah risiko insufisiensi adrenal kategori sedang (β=-2,747; p=0,004) dan kategori tinggi (β=-7,609; p3 minggu, terdapat hubungan negatif yang signifikan antara kadar trigliserida dan kadar kortisol serum pada analisis bivariat. namun, setelah dilakukan penyesuaian terhadap faktor-faktor klinis dan metabolik, kadar trigliserida tidak terbukti sebagai prediktor independen kadar kortisol serum. kata kunci: kortisol, trigliserida, steroid kronik, insufisiensi adrenal, resistensi insulin.

Chronic steroid use may suppress the hypothalamic–pituitary–adrenal (HPA) axis, leading to adrenal insufficiency and affecting various metabolic processes, including lipid metabolism. The relationship between cortisol and triglyceride levels in chronic steroid users remains incompletely understood, particularly among patients at risk of adrenal insufficiency. This study aimed to evaluate the association between triglyceride levels and serum cortisol levels in chronic steroid users with a risk of adrenal insufficiency. This analytical observational study with a cross-sectional design was conducted among 53 chronic steroid users attending the Internal Medicine Outpatient Clinic of Dr. Zainoel Abidin General Hospital, Banda Aceh. Participants were recruited using consecutive sampling according to predefined inclusion and exclusion criteria. Serum cortisol levels were measured using enzyme-linked immunosorbent assay (ELISA), while triglyceride levels were assessed using an enzymatic colorimetric method. Associations were analyzed using Spearman’s correlation test followed by multivariable linear regression analysis. Spearman’s correlation analysis demonstrated a significant negative correlation between serum cortisol and triglyceride levels (r=−0.302, p=0.024). Each 1 mg/dL increase in triglyceride levels was associated with a 0.019 μg/dL decrease in serum cortisol levels (β=−0.019; p=0.025). However, multivariable linear regression analysis showed that triglyceride levels were not independently associated with serum cortisol levels (β=−0.002, p=0.394). Factors significantly associated with serum cortisol levels included moderate adrenal insufficiency risk (β=-2,747; p=0,004), high adrenal insufficiency risk (β=-7,609; p3 weeks, triglyceride levels were inversely associated with serum cortisol levels in the bivariate analysis. However, after adjustment for clinical and metabolic factors, triglyceride levels were not identified as an independent predictor of serum cortisol levels. Keywords: cortisol, triglycerides, chronic steroid use, adrenal insufficiency, insulin resistance