Electronic Theses and Dissertation

Abstrak latar belakang: stroke iskemik merupakan penyebab utama morbiditas dan mortalitas neurologis. aterosklerosis intrakranial merupakan salah satu mekanisme penting yang mendasari terjadinya stroke iskemik. fibrinogen berperan dalam proses inflamasi dan trombosis yang dapat mempercepat pembentukan serta progresivitas plak aterosklerotik. namun, hubungan antara kadar fibrinogen dengan luas aterosklerosis intrakranial pada pasien stroke iskemik masih belum banyak dilaporkan. tujuan: mengetahui hubungan kadar fibrinogen dengan luas aterosklerosis intrakranial pada pasien stroke iskemik. metode: penelitian observasional analitik dengan desain potong lintang pada 80 pasien stroke iskemik. kadar fibrinogen plasma diperiksa menggunakan metode clot-based assay (mechanical clot detection). penilaian luas aterosklerosis intrakranial dilakukan dengan digital subtraction angiography (dsa). analisis statistik menggunakan uji korelasi dengan tingkat kemaknaan p

Introduction: Ischemic stroke is a major cause of neurological morbidity and mortality. Intracranial atherosclerosis is one of the key mechanisms underlying ischemic stroke. Fibrinogen plays an important role in inflammation and thrombosis, contributing to the formation and progression of atherosclerotic plaques. However, evidence regarding the association between fibrinogen levels and the extent of intracranial atherosclerosis in ischemic stroke patients remains limited. Aim: To determine the association between plasma fibrinogen levels and the extent of intracranial atherosclerosis in patients with ischemic stroke. Methods: An analytic observational study with a cross-sectional design was conducted involving 80 patients with ischemic stroke. Plasma fibrinogen levels were measured using a clot-based assay (mechanical clot detection method). The extent of intracranial atherosclerosis was assessed using Digital Subtraction Angiography (DSA). Statistical analysis was performed using correlation tests with a significance level of p