Electronic Theses and Dissertation

Interleukin-20 (il-20) dan vitamin d berperan dalam respons imun, inflamasi, dan fibrogenesis pada penyakit hati kronik akibat infeksi virus hepatitis b dan c. prognosis sirosis hepatis umumnya dinilai menggunakan skor child–pugh, namun hubungan kadar il-20 dan vitamin d dengan skor tersebut masih belum jelas. penelitian ini bertujuan untuk menilai hubungan kadar il-20 dan vitamin d 25-hidroksi [25(oh)d] dengan skor child–pugh pada pasien sirosis hepatis akibat infeksi virus hepatitis. penelitian analitik observasional dengan desain cross-sectional dilakukan pada april–desember 2025 di rsud dr. zainoel abidin, banda aceh. sebanyak 30 pasien sirosis hepatis direkrut secara purposive sampling. kadar il-20 dan vitamin d 25(oh) diperiksa menggunakan metode elisa, sedangkan keparahan sirosis dinilai dengan skor child–pugh. analisis dilakukan menggunakan uji kruskal–wallis. rerata usia subjek penelitian adalah 53,8±12,0 tahun, dengan dominasi pasien laki-laki. mayoritas pasien berada pada child–pugh kelas b (60,0%), diikuti kelas c (26,7%) dan kelas a (13,3%). median kadar vitamin d tergolong rendah dan menunjukkan kecenderungan menurun seiring peningkatan skor child–pugh, namun tidak signifikan secara statistik (p=0,222). median kadar il-20 cenderung meningkat pada derajat keparahan yang lebih berat, tetapi perbedaan antar kelompok child–pugh juga tidak signifikan (p=0,179). selain itu, uji korelasi spearman menunjukkan tidak terdapat hubunngan antara kadar il-20 dan vitamin d (r=0,250; p=0,182). kesimpulannya, kadar vitamin d cenderung menurun dan kadar il-20 cenderung meningkat seiring bertambahnya keparahan sirosis berdasarkan skor child–pugh, meskipun hubungan tersebut tidak signifikan secara statistik. hasil penelitian ini menunjukkan bahwa vitamin d dan il-20 berpotensi mencerminkan perubahan imunologis dan metabolik pada sirosis hepatis, namun peran keduanya sebagai penanda prognosis klinis memerlukan penelitian lanjutan dengan ukuran sampel yang lebih besar. kata kunci: sirosis hepatis, interleukin-20, vitamin d, child–pugh, hepatitis virus.  

Interleukin-20 (IL-20) and vitamin D play roles in immune responses, inflammation, and fibrogenesis in chronic liver disease caused by hepatitis B and C virus infections. Prognosis of hepatic cirrhosis is commonly assessed using the Child–Pugh score; however, the associations between IL-20 and vitamin D levels and this score remain unclear. This study aimed to evaluate the relationships between IL-20 and 25-hydroxyvitamin D [25(OH)D] levels and the Child–Pugh score in patients with hepatic cirrhosis due to viral hepatitis. An analytic observational study with a cross-sectional design was conducted from April to December 2025 at Dr. Zainoel Abidin Regional General Hospital, Banda Aceh. A total of 30 patients with hepatic cirrhosis were recruited using purposive sampling. Serum IL-20 and 25(OH)D levels were measured using enzyme-linked immunosorbent assay, while cirrhosis severity was assessed using the Child–Pugh score. Statistical analysis was performed using the Kruskal–Wallis test. The mean age of participants was 53.8±12.0 years, with a predominance of male patients. Most patients were classified as Child–Pugh class B (60.0%), followed by class C (26.7%) and class A (13.3%). Median vitamin D levels were low and showed a decreasing trend with increasing Child–Pugh class, although this difference was not statistically significant (p=0.222). Median IL-20 levels tended to increase with greater disease severity; however, differences among Child–Pugh classes were also not statistically significant (p=0.179). In addition, Spearman correlation analysis showed no significant association between IL-20 and vitamin D levels (r=0.250; p=0.182). In conclusion, vitamin D levels tended to decrease and IL-20 levels tended to increase with increasing cirrhosis severity based on the Child–Pugh score, although these associations were not statistically significant. These findings suggest that vitamin D and IL-20 may reflect immunological and metabolic alterations in hepatic cirrhosis; however, further studies with larger sample sizes are required to clarify the prognostic value of both biomarkers. Keywords: hepatic cirrhosis, interleukin-20, vitamin D, Child–Pugh, viral hepatitis.