Electronic Theses and Dissertation

Analisis kadar fecal short chain fatty acid, serum interleukin-6 dan gejala psikologis pada pasien sindrom kolon iritabel latar belakang: sindrom iritasi usus (ibs) adalah gangguan gastrointestinal fungsional yang sering disertai dengan disbiosis mikrobiota usus, peradangan ringan, dan tekanan psikologis. asam lemak rantai pendek (scfa) dan interleukin-6 (il-6) diduga berperan dalam patogenesis ibs dan dikaitkan dengan gejala psikologis melalui poros mikrobiota-usus-otak, tetapi hubungannya masih belum jelas. tujuan: untuk menganalisis hubungan antara kadar scfa feses, kadar il-6 serum, dan gejala psikologis pada pasien ibs. metode: studi potong lintang yang melibatkan 40 pasien ibs berdasarkan kriteria roma iv. scfa feses, il-6 serum, dan gejala psikologis diperiksa. hasil: sebagian besar subjek memiliki kadar scfa normal. tidak ditemukan hubungan yang signifikan antara kadar scfa terhadap il-6 serum (p = 0,177), kadar scfa terhadap gejala psikologis (p = 0,241), dan kadar il-6 serum terhadap gejala psikologis (p = 0,333). kesimpulan: tidak ada hubungan signifikan antara kadar scfa feses, il-6 serum, dan gejala psikologis pada pasien ibs. kata kunci: sindrom iritasi usus besar, scfa, il-6, sumbu mikrobiota-usus-otak.

ANALYSIS OF FECAL SHORT-CHAIN FATTY ACID LEVELS, SERUM INTERLEUKIN-6 LEVELS, AND PSYCHOLOGICAL SYMPTOMS IN PATIENTS WITH IRRITABLE BOWEL SYNDROME Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder often accompanied by gut microbial dysbiosis, low-grade inflammation, and psychological distress. Short-chain fatty acids (SCFAs) and interleukin-6 (IL-6) are thought to play a role in the pathogenesis of IBS and are associated with psychological symptoms through the microbiota–gut–brain axis, but the association remains unclear. Objective: To analyze the association between fecal SCFA levels, serum IL-6 levels, and psychological symptoms in IBS patients. Methods: A cross-sectional study involving 40 IBS patients based on Rome IV criteria. Fecal SCFA, serum IL-6, and psychological symptoms were examined. Results: Most subjects had normal SCFA levels. No significant association was found between SCFA levels and serum IL-6 (p = 0.177), SCFA levels and psychological symptoms (p = 0.241), or serum IL-6 levels and psychological symptoms (p = 0.333). Conclusion: There is no significant association between fecal SCFA levels, serum IL-6, and psychological symptoms in IBS patients. Keywords: irritable bowel syndrome, SCFA, IL-6, microbiota–gut–brain axis.