Electronic Theses and Dissertation

Pendahuluan: ketidakseimbangan lipid berperan penting dalam perkembangan aterosklerosis, namun hubungan antara parameter lipid dan stenosis arteri serebral yang dikonfirmasi melalui angiografi pada pasien stroke iskemik masih jarang diteliti pada populasi indonesia. tujuan: penelitian ini bertujuan untuk menganalisis hubungan antara parameter lipid termasuk kolesterol total, low-density lipoprotein cholesterol (ldl-c), high-density lipoprotein cholesterol (hdl-c), trigliserida, rasio ldl-c/hdl-c, dan rasio kolesterol total/hdl-c dengan derajat stenosis arteri serebral yang diukur menggunakan digital subtraction angiography (dsa) pada pasien stroke iskemik di indonesia. metode: penelitian potong lintang ini dilakukan di rumah sakit umum daerah dr. zainoel abidin, banda aceh, indonesia, pada periode mei hingga oktober 2025. profil lipid puasa yang meliputi kolesterol total, ldl-c, hdl-c, dan trigliserida diukur, kemudian rasio ldl-c/hdl-c dihitung. stenosis arteri serebral dinilai menggunakan dsa. hasil: penelitian ini menemukan bahwa kadar kolesterol total, ldl-c, trigliserida, serta rasio ldl-c/hdl-c dan kolesterol total/hdl-c meningkat seiring dengan tingkat keparahan stenosis, sedangkan kadar hdl-c menurun secara signifikan (p

Introduction: Lipid imbalance plays a crucial role in atherosclerosis development, yet the association between lipid parameters and angiographically confirmed cerebral arterial stenosis in ischemic stroke remains underexplored in the Indonesian population. Aim: This study aimed to analyze the association between lipid parameters— including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, LDL-C/HDL-C ratio, and total cholesterol/HDL-C ratio—and the degree of cerebral arterial stenosis measured by Digital Subtraction Angiography (DSA) in Indonesian patients with ischemic stroke. Methods: A cross-sectional study was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, from May to October 2025. Fasting lipid profiles, including total cholesterol, LDL-C, HDL-C, and triglycerides, were measured, and the LDLC/HDL-C ratio was calculated. Cerebral arterial stenosis was assessed using DSA. Results: The present study found that total cholesterol, LDL-C, triglycerides, and both LDL-C/HDL-C and total cholesterol/HDL-C ratios increased with stenosis severity, while HDL-C declined significantly (p