Electronic Theses and Dissertation

Endometriosis merupakan penyakit ginekologi kronis akibat pertumbuhan jaringan endometrium di luar kavum uteri, sering disertai nyeri panggul, dismenorea, dan infertilitas. diagnosis pasti masih bergantung pada laparoskopi yang invasif, sehingga diperlukan biomarker non-invasif seperti cancer antigen-125 (ca-125). namun, hubungan kadar ca-125 dengan karakteristik klinis pasien endometriosis masih bervariasi. penelitian ini bertujuan menganalisis hubungan kadar ca-125 dengan usia, dismenorea, infertilitas, dan obesitas pada pasien endometriosis. desain penelitian adalah analitik retrospektif dengan pendekatan cross sectional terhadap 45 pasien endometriosis yang menjalani pemeriksaan ca-125 di rsud dr. zainoel abidin banda aceh periode januari 2024–juli 2025. data diperoleh dari rekam medis menggunakan teknik total sampling. analisis hubungan dilakukan dengan uji mann–whitney dan perhitungan sensitivitas ca-125. terdapat hubungan signifikan antara kadar ca-125 dengan usia (p

Endometriosis is a chronic gynecological disease characterized by the growth of endometrial tissue outside the uterine cavity, commonly associated with pelvic pain, dysmenorrhea, and infertility. Definitive diagnosis still relies on invasive laparoscopy; therefore, a reliable non-invasive biomarker such as Cancer Antigen-125 (CA-125) is needed. However, previous studies have shown inconsistent results regarding the association between CA-125 levels and clinical characteristics of endometriosis patients.This study aimed to analyze the relationship between CA-125 levels and age, dysmenorrhea, infertility, and obesity in endometriosis patients. An analytic retrospective design with a cross-sectional approach was used on 45 endometriosis patients who underwent CA-125 examination at dr. Zainoel Abidin General Hospital, Banda Aceh, from January 2024 to July 2025. Data were obtained from medical records using total sampling. Statistical analysis was performed using the Mann–Whitney test and sensitivity assessment of CA-125 as a diagnostic marker. CA-125 levels showed a significant negative association with age (p