Electronic Theses and Dissertation

Streptococcus merupakan salah satu genus bakteri gram positif famili streptococcaceae yang menyebabkan berbagai infeksi pada manusia. penelitian ini bertujuan untuk mengetahui distribusi frekuensi streptococcus berdasarkan spesimen klinik, jenis kelamin, usia dan ruang rawat serta pola antibiogram streptococcus periode januari 2020 hingga maret 2025 di rsud dr. zainoel abidin. penelitian ini menggunakan metode observasi laboratorium dengan desain cross-sectional. data diambil dari laboratorium mikrobiologi klinik rsud dr. zainoel abidin secara retrospektif januari 2020 hingga desember 2024 dan secara prospektif januari hingga maret 2025. bakteri diisolasi pada media blood agar dan dilakukan identifikasi serta uji sensitivitas antibiotik menggunakan alat otomatis vitek® 2 compact. hasil penelitian diperoleh 22 spesies dan 5 subspesies streptococcus dari total 353 isolat streptococcus yang teridentifikasi dari spesimen klinik. distribusi spesies paling dominan yaitu streptococcus agalactiae (26,63%), diikuti dengan streptococcus gallolyticus (15,58%) dan streptococcus constellatus (7,93%). subspesies streptococcus yang teridentifikasi terdiri dari streprococcus dysgalactiae subsp. dysgalactia, streptococcus dysgalactiae subsp. equisimilis, streptococcus constellatus subsp. constellatus, streptococcus constellatus subsp. pharyngis, dan streptococcus gallolyticus subsp. pasteurianus. distribusi frekuensi streptococcus berdasarkan spesimen klinik paling banyak ditemukan pada spesimen pus yaitu (20,11%), diikuti dengan swab mukosa (18,98%) dan sputum (17,56%). berdasarkan jenis kelamin dan usia paling banyak pada laki-laki yaitu (50,99%) dengan rentang usia 40 – 59 tahun (35,41%). distribusi streptococcus berdasarkan ruang rawat paling banyak ditemukan di ruang rawat jantung dan paru (15,58%). streptococcus memiliki sensitivitas yang tinggi terhadap antibiotik tigecycline (97,77%), amoxicillin/clauvulanic acid (93,40%) dan amoxicillin (92,84%) serta resistansi terhadap antibiotik oxacillin (19,75%), cefoxitin (11,19%), gentamicin (21,31%), dan tetracycline (30,53%). hasil penelitian ini menunjukkan bahwa streptococcus yang terisolasi dari spesimen klinik di rsud dr. zainoel abidin memiliki tingkat sensitivitas yang masih cukup baik. kata kunci: antibiogram, sensitivitas, spesimen klinik, streptococcus

Streptococcus is a genus of Gram-positive bacteria in the Streptococcaceae family that causes various infections in humans. This study aims to determine the frequency distribution of Streptococcus based on clinical specimens, gender, age and treatment room and the pattern of Streptococcus antibiograms from January 2020 to March 2025 at Dr. Zainoel Abidin Hospital. This study used a laboratory observation method with a cross-sectional design. Data were taken from the Clinical Microbiology Laboratory of Dr. Zainoel Abidin Hospital retrospectively from January 2020 to December 2024 and prospectively from January to March 2025. Bacteria were isolated on Blood Agar media and identified and tested for antibiotic sensitivity using the VITEK® 2 Compact automatic tool. The results of the study obtained 22 species and 5 subspecies of Streptococcus from a total of 353 Streptococcus isolates identified from clinical specimens. The most dominant species distribution was Streptococcus agalactiae (26.63%), followed by Streptococcus gallolyticus (15.58%) and Streptococcus constellatus (7.93%). The identified Streptococcus subspecies consisted of Streprococcus dysgalactiae subsp. dysgalactia, Streptococcus dysgalactiae subsp. equisimilis, Streptococcus constellatus subsp. constellatus, Streptococcus constellatus subsp. pharyngis, and Streptococcus gallolyticus subsp. pasteurianus. The frequency distribution of Streptococcus based on clinical specimens was most commonly found in pus specimens (20.11%), followed by mucosal swabs (18.98%) and sputum (17.56%). Based on gender and age, the most common were men (50.99%) with an age range of 40-59 years (35.41%). The distribution of Streptococcus based on the treatment room was mostly found in the heart and lung treatment room (15.58%). Streptococcus has high sensitivity to tigecycline antibiotics (97.77%), amoxicillin/clauvulanic acid (93.40%) and amoxicillin (92.84%) and resistance to Oxacillin antibiotics (19.75%), cefoxitin (11.19%), gentamicin (21.31%), and tetracycline (30.53%). The results of this study indicate that Streptococcus isolated from clinical specimens at Dr. Zainoel Abidin Regional Hospital has a fairly good level of sensitivity. Keywords: Antibiogram, sensitivity, clinical specimens, Streptococcus