Electronic Theses and Dissertation

Luka yang terkontaminasi dapat menghambat proses penyembuhan luka. daun kirinyu (chromolaena odorata) diketahui memiliki berkhasiat dalam proses penyembuhan luka. tujuan dari penelitian ini adalah untuk mengetahui potensi ekstrak air daun (chromolaena odorata) terhadap angiogenesis, fibroblas dan epitelisasi pada luka terkontaminasi. tiga puluh enam ekor mencit jantan dewasa dibagi menjadi 2 kelompok. luka pada kulit dilakukan dengan eksisi tangensial 2x2cm pada daerah dorsal dan diberi kontaminasi staphylococcus aureus. kelompok i mendapat larutan garam normal 0,9% dan kelompok ii mendapat ekstrak air daun kirinyu (chromolaena odorata) 7,5%. terapi diberikan satu kali tepat setelah kontaminasi dilakukan. gambaran makroskopis dan variabel mikroskopis (angiogenesis, fibroblas dan ketebalan epitel) diamati pada h-21 dengan pewarnaan hematoksilin-eosin. seluruh variabel numerik dianalisis secara statistik. hasil penelitian menunjukkan gambaran makroskopis lebih baik pada kelompok chromolaena odorata dan terdapat perbedaan signifikan pada angiogenesis, fibroblas dan ketebalan epitel (p

Contaminated wound can inhibit the wound healing process. Chromolaena odorata known have wound healing properties. Aim of this study is to determine the potential of aqueous extract of kirinyu leaf (Chromolaena odorata) on angiogenesis, fibroblasts, and epithelization in contaminated wound. Thirty six adult male mice were divided into 2 groups. Skin wound were perform by tangential excision of 2x2cm in dorsal area and given a Staphylococcus aureus contamination. Group I received 0.9% normal saline and group II received aqueous extract of kirinyu leaf (Chromolaena odorata) 7.5%. Therapy was given in a single time exactly after the contamination was done. Macroscopic view and microscopic variabel (angiogenesis, fibroblast and epithelial thickness) were observed on D-21 with hematoxylin-eosin stainings. All numeric variabel were analyzed statistically. The results showed macroscopic view was better in Chromolaena odorata group and there are significant difference in angiogenesis, fibroblast and epithelial thickness (p