Electronic Theses and Dissertation

Nanokomposit fiber (nf) nilon 6,6-agnps yang memiliki sifat antibakteri telah berhasil disintesis dengan menggunakan metode electrospinning dengan konsentrasi agno3 divariasikan. parameter optimum electrospinning untuk sintesis nf nilon 6,6-agnps didapatkan pada konsentrasi larutan nilon 6,6 sebesar 20%, laju alir sebesar 100 μl/jam, jarak tip ke kolektor sejauh 15,5 cm, kelembaban sebesar 46-53%, voltase sebesar 24,8 kv dan proses sintesis electrospinning selama 4,5 jam. nanokomposit fiber nilon 6,6-agnps selanjutnya dikarakterisasi dengan scanning electron microscopy (sem), transmission electron microscopy (tem), x-ray diffraction (xrd), fourier transform infra red spectroscopy (ftir), uji kuat tarik, uji sudut kontak, dan uji aktivitas antibakteri. hasil sem menunjukkan mikrofiber nilon 6,6 yang disintesis memiliki rentang diameter sebesar 300-1200 nm dan nf nilon 6,6-agnps sebesar 200-600 nm, di mana diameter ukuran fiber mengecil seiring dengan peningkatan konsentrasi agno3. hasil tem menunjukkan agnps terdistribusi secara merata pada permukaan nf nilon 6,6 dengan rentang ukuran agnps yang dihasilkan sebesar 5,656-8,222 nm. keberadaan agnps dibuktikan dengan hasil xrd yang menunjukkan puncak ag yang semakin tinggi seiring peningkatan konsentrasi agno3. nf nilon 6,6-agnps memiliki sifat mekanis yang baik dan sesuai dengan kisaran kulit normal manusia. selain itu, penambahan agnps meningkatkan sifat antibakteri nf nilon 6,6-agnps terhadap bakteri s. aureus dan e. coli, sehingga nanokomposit fiber nilon 6,6-agnps yang disintesis dengan metode electrospinning memiliki potensi yang dapat dikembangkan sebagai pembalut luka. kata kunci: electrospinning; nanofiber; nilon 6,6; agnps; aktivitas antibakteri

Nylon 6,6-AgNPs nanocomposite fibers (NFs) with antibacterial properties have been successfully synthesized using the electrospinning method with variation of AgNO3 concentration. The optimum electrospinning parameters for the synthesis of nylon 6,6-AgNPs NFs were found to be 20% concentration of nylon 6,6 solution, 100 μL/hour flow rate, 15.5 cm tip to collector distance, 46-53% humidity, 24.8 kV voltage, and 4.5 hours electrospinning synthesis process. The nylon 6,6-AgNPs NFs were further characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), X-Ray Diffraction (XRD), Fourier Transform Infra Red Spectroscopy (FTIR), tensile strength test, contact angle test, and antibacterial activity test. SEM showed that nylon 6,6 microfibers had a diameter range of 300-1200 nm and nylon 6,6-AgNPs NFs of 200-600 nm, with smaller fiber size as the AgNO3 concentration increased. TEM data showed AgNPs were evenly distributed on the surface of NF nylon 6,6 with size range of 5.656-8.222 nm. The existence of AgNPs is proven by XRD which showed higher Ag peaks as the AgNO3 concentration increased. The nylon 6,6-AgNPs NFs have good mechanical properties and corresponding to the normal human skin range. In addition, the presence of AgNPs improved the antibacterial properties of nylon 6,6-AgNPs NFs against S. aureus and E. coli, thus nylon 6,6-AgNPs nanocomposite fibers synthesized by electrospinning have the potential to be developed as wound dressing. Keywords: electrospinning; nanofiber; nylon 6,6; AgNPs; antibacterial activity