Electronic Theses and Dissertation

Daun johar (cassia siamea l.) telah digunakan sebagai obat tradisional di indonesia termasuk untuk mengobati diabetes melitus. penelitian ini bertujuan untuk menyelidiki aktivitas antidiabetes dari ekstrak air daun johar pada tikus yang diinduksi streptozotocin sekaligus mengetahui dosis efektif 50% (ed50). metode penelitian ini menggunakan rancangan pretest postest with control group design. kadar glukosa darah tikus diukur setelah diinduksi streptozotocin dan setelah perlakuan. data dianalisis dengan uji one way anova (analysis of variance) dilanjutkan dengan uji post hoc duncan. hasil penelitian menunjukkan adanya penurunan kadar glukosa darah tikus setelah pemberian ekstrak air daun johar selama 7 hari. efeknya setara dengan metformin dosis 10 mg/kgbb. nilai ed50 ekstrak air daun johar adalah 95 mg/kgbb. dengan demikian, ekstrak air daun johar sangat potensial sebagai obat alternatif diabetes melitus. kata kunci : ekstrak air daun johar, diabetes melitus, kadar glukosa darah

Johar leaves (Cassia siamea L.) has been used as a traditional medicine in Indonesia, including the treatment of diabetes mellitus. This study aims to investigate the antidiabetic activity of aqueous extract of johar leaves in streptozotocin-induced rats and to determine the 50% effective dose (ED50). This research method uses a pretest-postest design with control group. Blood glucose levels of rats were measured after streptozotocin induction and after treatment. Data were analyzed by one-way ANOVA (analysis of variance) followed by post hoc Duncan test. The results showed a decrease in blood glucose levels of rats after administration of water extract of johar leaves for 7 days. The effect is equivalent to metformin dose of 10 mg/kgBB. The ED50 value of water extract of johar leaves is 95 mg/kg BB. Thus, the water extract of johar leaves is very potential as an alternative medicine for diabetes mellitus. Keywords: Aqueous Extract of Johar Leaves, Diabetes Mellitus, Blood Sugar Levels