Electronic Theses and Dissertation

Pendahuluan: ketuban pecah dini (kpd) menjadi salah satu penyebab tingginya angka kematian bayi dan kesakitan ibu di negara berkembang termasuk indonesia. upaya diagnosis secara cepat dan tepat serta efisien dalam pembiayaan diperlukan untuk dapat dengan segera memberikan penanganan pada penderita kpd. penelitian ini bertujuan untuk menilai kemaknaan diagnostik pemeriksaan nitrazin terhadap baku emas pemeriksaan protein insulin like growth factor binding-1 (igfbp-1) dalam mendiagnosis kpd. metode: penelitian ini termasuk studi diagnostik dengan desain potong lintang pada rumah sakit umum daerah dr. zainoel abidin banda aceh. pemeriksaan nitrazine dilakukan menggunakan kertas lakmus dan pemeriksaan protein igfbp- 1 dilakukan menggunakan actim prom rapid test. analisis perbedaan antar kedua pemeriksaan dilakukan dengan chi-squared test dengan kemaknaan 95%. hasil: sebanyak 50 ibu dengan dugaan kpd terlibat dalam penelitian ini dengan dominasi usia 28,58 tahun dan usia kehamilan 34 – 38 minggu. pemeriksaan nitrazin menunjukkan sensitifitas 92,86%, spesifisitas 50%, nilai duga positif 41,49%, nilai duga negatif 94,74% serta akurasi 62%. terdapat perbedaan kemaknaan diagnositik yang signifikan antara nitrazin dan igfbp-1 dalam mendiagnosis kpd (p = 0,005). kesimpulan: pemeriksaan nitrazine dapat dijadikan modalitas yang aman untuk penapisan diagnosis kpd oleh karena menunjukkan nilai sensitifitas dan nilai duga negatif yang baik terhadap pemeriksaan baku emas igfbp-1. kata kunci: ketuban pecah dini, nitrazine, igfbp-1, kemaknaan diagnosis

Introduction: Premature rupture of membranes (PROM) is one of the causes of high infant mortality and maternal morbidity in developing countries including Indonesia. Efforts to diagnose it quickly and efficiently in financing are needed to be able to immediately provide treatment to PROM patients. This study aims to assess the diagnostic significance of Nitrazine examination against the gold standard of Insulin Like Growth Factor Binding-1 (IGFBP-1) protein examination in diagnosing PROM. Methods: This study was a diagnostic study with a cross-sectional design at the Regional General Hospital dr. Zainoel Abidin Banda Aceh. Nitrazine examination was carried out using litmus paper and IGFBP-1 protein examination was carried out using the Actim PROM rapid test. Analysis of differences between the two examinations was carried out using the Chi-squared test with a significance of 95%. Results: A total of 50 women with suspected PROM were involved in this study with a predominance of 28.58 years of age and 32 - 37 weeks of gestation. Nitrazine examination showed a sensitivity of 92.86%, a specificity of 50%, a positive predictive value of 41.49%, a negative predictive value of 94.74% and an accuracy of 62%. There was a significant difference in diagnostic significance between Nitrazine and IGFBP-1 in diagnosing PROM (p = 0.005). Conclusion: Nitrazine examination can be used as a safe modality for screening for PROM diagnosis because it shows good sensitivity and negative predictive value of the IGFBP-1 gold standard examination. Keywords: Premature rupture of membranes, Nitrazine, IGFBP-1, diagnostic significance