Electronic Theses and Dissertation

Kurkumin merupakan senyawa polifenol kelompok flavonoid berbentuk bubuk berwarna orange dan tidak dapat larut dalam air. senyawa kurkumin memiliki sifat anti bakteri, anti proliferasi, anti inflamasi, antioksidan, anti karsinogenik, dan efek anti amyloidogenic sehingga banyak digunakan sebagai obat di kalangan masyarakat. penelitian terkait analisis laju pelepasan kurkumin dari kapsul dengan penyangga rengginang telah dilakukan. penelitian ini bertujuan untuk menganalisis laju pelepasan kurkumin dari kapsul dengan penyangga rengginang serta mengidentifikasi model kinetikanya, selain itu kurkumin diharapkan tersedia dalam tubuh lebih lama dan tidak langsung dicerna sehingga perlu ada upaya diperlambat laju pelepasannya agar tubuh selalu memiliki simpanan kurkumin. metode spektrofotometri uv-vis digunakan untuk memonitor laju pelepasan kurkumin dari kapsul dengan penyangga rengginang dalam waktu 200 menit. hasil penelitian menunjukkan bahwa laju kurkumin terimmobilisasi rengginang dalam kapsul melepaskan 13,81%/menit dan jauh lebih lambat dari laju kurkumin tanpa rengginang dalam kapsul. oleh karena itu, penambahan penyangga rengginang dapat memperpanjang waktu pelepasan kurkumin dari kapsul.

Curcumin is a polyphenol compound belonging to the flavonoid group, in the form of an orange powder that is insoluble in water. Curcumin has antibacterial, anti-proliferative, anti-inflammatory, antioxidant, anti-carcinogenic, and anti-amyloidogenic properties, which makes it widely used as a medicine among the public. However, curcumin used as a medicine can have negative health impacts due to its poor solubility in water. Research on the analysis of the release rate of curcumin from capsules with sticky rice crackers has been conducted. The purpose of this study is to analyze the release rate of curcumin from capsules with a sticky rice crackers and to identify its kinetic model. Furthermore, curcumin is expected to be available in the body for a longer time and not be immediately digested, so there needs to be an effort to slow down the release rate to ensure that the body always has a reserve of curcumin. The UV-Vis spectrophotometer method was used to monitor the release rate of curcumin from capsules with a sticky rice crackers over a period of 200 minutes. The results shows that the rate of curcumin immobilized in the sticky rice crackers capsule was 13,81%/minute and much slower than the rate of curcumin without sticky rice crackers in the capsule. Therefore, the addition of sticky rice crackers can prolong the release time of curcumin from capsules.