Electronic Theses and Dissertation

Material bone graft yang disintesis dari hidroksiapatit alami cangkang faunus ater mengandung caco3 yang dapat digunakan untuk penanganan defek tulang. penelitian ini menggunakan 6 ekor kelinci yang dibuat defek pada diaphysis humerus terdiri dari 2 perlakuan. kelompok (pi) diimplan menggunakan hidroksiapatit (ha) disertai penambahan plasma kaya trombosit (pkt), dan kelompok (pii) diimplan hidroksiapatit (ha) tunggal. tulang humerus dikoleksi dihari ke-90 untuk pengamatan histopatologi pada sel osteoblas, osteosit, osteoklas, arteri nutrient, proliferasi bone marrow, nekrosis, dan orientasi kolagen. sediaan dibuat dengan teknik pewarnaan hemaktosilin dan eosin (he). hasil pengamatan dianalisis menggunakan uji multivariate menunjukan penggunaan material (ha) disertai penambahan (pkt) memperlihatkan gambaran histopatologi yang signifikan (p

Bone graft material synthesized from natural hydroxyapatite of Faunus ater shell contains CaCO3 which can be used for treating bone defects. This study used 6 rabbits that had defects in the humeral diaphysis consisting of 2 treatments. The (PI) group was implanted using hydroxyapatite (HA) accompanied by the addition of platelet-rich plasma (PKT), and the (PII) group was implanted with a single hydroxyapatite (HA). The humeral bones were collected on the 90th day for histopathological observations on osteoblast cells, osteocytes, osteoclasts, artery nutrient, bone marrow proliferation, necrosis, and collagen orientation. Preparations were made using hemactocillin and eosin (HE) staining techniques. The results of the observations were analyzed using the multivariate test showing that the use of material (HA) with the addition of (PKT) showed a significant histopathological picture (P