Electronic Theses and Dissertation

Fusobacterium nucleatum merupakan bakteri patogen yang berperan dalam penyakit periodontal seperti gingivitis dan periodontitis. salah satu cara untuk mengendalikan penyakit periodontal yaitu dengan pemberian bahan yang bersifat antibakteri. ekstrak daun kersen memiliki kandungan flavonoid, tanin, saponin dan alkaloid yang memiliki daya antibakteri. tujuan dari penelitian ini untuk mengetahui efektivitas daya hambat ekstrak daun kersen (muntingia calabura l) terhadap pertumbuhan bakteri fusobacterium nucleatum. metode yang digunakan adalah metode difusi menggunakan kertas cakram. pada penelitian ini menggunakan 7 kelompok penelitian yaitu ekstrak daun kersen (muntingia calabura l) dengan konsentrasi 6,25%, 12,5%, 25%, 50%, 100%, larutan chlorhexidine 0,2% sebagai kontrol positif, dan larutan dmso sebagai kontrol negatif. daya hambat antibakteri ditunjukkan dengan adanya zona hambat di sekitar kertas cakram. hasil penelitian menunjukkan adanya zona hambat ekstrak daun kersen pada konsentrasi 12,5%, 25%, 50% dan 100%. hasil uji kruskal-wallis didapatkan nilai signifikansi p=0,000 sehingga dapat dinyatakan bahwa ekstrak daun kersen (muntingia calabura l) memiliki pengaruh daya hambat terhadap pertumbuhan bakteri fusobacterium nucleatum. kesimpulannya ekstrak daun kersen (muntingia calabura l) memiliki efektivitas daya hambat terhadap pertumbuhan bakteri fusobacterium nucleatum. kata kunci: efektivitas daya hambat, antibakteri, ekstrak daun kersen, muntingia calabura l , fusobacterium nucleatum.

Fusobacterium nucleatum is a pathogenic bacterium that plays a role in periodontal diseases such as gingivitis and periodontitis. One way to control periodontal disease is by administering antibacterial agents. Kersen leaf extract contains flavonoids, tanins, saponins and alkaloids which have antibacterial properties. The purpose of this study is to determine the inhibition effectiveness of kersen leaf extract (Muntingia calabura L) on the growth of the Fusobacterium nucleatum bacterium. The method used was the diffusion method using paper disc. In this study, 7 research groups were used, namely kersen leaf extract (Muntingia calabura L) with a concentration of 6.25%, 12.5%, 25%, 50%, 100%, Chlorhexidine 0.2% as positive control, and DMSO solution as negative control. Antibacterial inhibition was indicated by the presence of an inhibition zone around the paper disc. The results show that there is inhibition zones of kersen leaf extract at concentrations of 12.5%, 25%, 50% and 100%. The Kruskal-Wallis test results obtain a significance value of p = 0.000 so that it can be state that kersen leaf extract (Muntingia calabura L) has an inhibitory effect on the growth of the bacterium Fusobacterium nucleatum. In conclusion, kersen leaf extract (Muntingia calabura L) has an inhibition effectiveness towards the growth of the Fusobacterium nucleatum bacterium. Keywords: The inhibition effectiveness, Antibacterial, Kersen leaves extract, Muntingia calabura L, Fusobacterium nucleatum.