Electronic Theses and Dissertation

Daun mimba (azadirachta indica a.juss) dan daun gandarusa (justicia gendarussa burm.f) saat ini banyak diteliti untuk pengembangan senyawa antifertilitas. namun, efek pemberian kedua herbal terhadap konsentrasi testosteron masih terbatas. penelitian ini bertujuan untuk mengetahui konsentrasi testosteron pada kelinci jantan setelah diberikan kombinasi ekstrak daun mimba dan daun gandarusa selama 52 hari. penelitian ini menggunakan rancangan acak lengkap (ral) terdiri dari tiga taraf perlakuan dengan tiga ulangan yaitu perlakuan p1 (kontrol) : tidak diberikan ekstrak, kelompok kedua p2: kombinasi 100 mg/kg bb ekstrak daun mimba dan 100 mg/kg bb ekstrak daun gandarusa, dan p3: kombinasi 150 mg/kg bb ekstrak daun mimba dan 150 mg/kg bb ekstrak daun gandarusa. penelitian ini menggunakan sembilan ekor kelinci jantan, berumur 1-1,5 tahun, bobot badan 2,0-2,5 kg. pemberian kombinasi ekstrak daun mimba dan gandarusa dilakukan secara oral menggunakan sonde lambung selama 52 hari. data dianalisis menggunakan uji ragam (one way anova) dan dilanjutkan dengan uji duncan. hasil penelitian menunjukkan bahwa konsentrasi testosteron berbeda nyata antar perlakuan (p

Neem leaves (Azadirachta indica A.Juss) and gandarusa leaves (Justicia gendarussa Burm.f) are currently being studied for the development of antifertility compounds. However, the effect of giving both herbs on testosterone concentrations is still limited. This study aims to determine the concentration of testosterone in male rabbits after being given a combination of neem and gandarusa leaf extracts for 52 days. This study used a completely randomized design (CRD) consisting of three treatments with three replications, P1 (control treatment): no extract was given P2: a combination of 100 mg/kg BB of neem leaf extract and 100 mg/kg BB of gandarusa leaf extract. , and P3: a combination of 150 mg/kg BW of neem leaf extract and 150 mg/kg BB of gandarusa leaf extract. This study used nine male rabbits, aged 1-1.5 years, body weight 2.0-2.5 kg. The combination of neem and gandarausa leaf extracts was administered orally using a gastric probe for 52 days. The data were analyzed using the test of variance (One Way ANOVA) and it was continued with Duncan's test. The results of the study, testosterone concentrations showed a significant difference between treatments (P