Electronic Theses and Dissertation

Abstrak analisis hematologi sebagai prediktor prognostik pada pasien covid-19 latar belakang covid-19 merupakan pandemi global yang serius yang dapat menyebabkan kematian. pemerikasaan laboratorium darah merupakan hal yang penting untuk mengevaluasi keparahan dan outcome pasien covid-19. penelitian ini bertujuan untuk membandingkan parameter hematologi berdasarkan derajat keparahan, outcome (hidup dan meninggal), serta mencari nilai cut off sebagai prediktor prognosis. metode penelitian ini berupa kohort retrospektif. sampel penelitian adalah penderita covid-19 dewasa di rsud dr. zainoel abidin banda aceh priode januari-desember 2021. data demografi, derajat keparahan, laboratorium darah serta hasil akhir rawatan diambil dari rekam medis. uji kruskal-wallis, uji t yang tidak berpasangan serta kurva receiver operating characteristic (roc) dilakukan pada penelitian ini. hasil sampel penelitian ini berjulmlah 362 orang. terdapat perbedaan signifikan pada hemoglobin, leukosit, eosinofil, basofil, netrofil, limfosit, monosit, nlr, mlr, plr, inr, rasio aptt, d-dimer dan fibrinogen antara derajat ringan, sedang dan berat. didapatkan juga perbedaan yang signifikan pada leukosit, eosinofil, netrofil, limfosit, monosit, nlr, mlr, plr, inr, d-dimer dan fibrinogen pada pasien yang hidup dan meninggal. nilai titik potong optimal pada leukosit 11x103 sel/mm3 (p

ABSTRACT HEMATOLOGIC ANALYSIS AS A PROGNOSTIC PREDICTOR OF COVID 19 PATIENTS Background COVID-19 is a serious global pandemic problem lead to mortality. Laboratory tests are important to evaluate the severity and outcome of COVID-19 patients. This study aims to compare hematologi parameters in severity of disease, outcome (survival prognosis) and to find the cut off value as a predictor of prognosis. Method This retrospective cohort were conducted in dr. Zainoel Abidin General Hospital Banda Aceh during January-December 2021. Demographic data, severity, blood laboratories and the final results of treatment were taken from medical records. Kruskal-Wallis test, Unpaired t-test and Receiver Operating Characteristic (ROC) curve were used to analized this study. Result Samples of this study were 362 people. There were significant differences in Hemoglobin, Leukocytes, Eosinophils, Basophils, Neutrophils, Lymphocytes, Monocytes, NLR, MLR, PLR, INR, aPTT ratio, D-dimer and Fibrinogen between mild, moderate and severe degrees. There were also significant differences in leukocytes, eosinophils, neutrophils, lymphocytes, monocytes, NLR, MLR, PLR, INR, D-dimer and Fibrinogen in survival prognosis. The optimal cut-off point for leukocyte was 11x103 cells/mm3 (p