Electronic Theses and Dissertation

ABSTRAK

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak tomat Lycopersicum esculentum L.) terhadap patologi anatomi testis tikus putih (Rattus novergicus) yang mengalami torsio unilateral 720o selama 6 jam. Sebanyak 20 ekor tikus putih (Rattus novergicus) strain Wistar, berjenis kelamin jantan, usia 3-4 bulan dengan bobot 180-200 gram, dibagi secara acak menjadi 4 kelompok perlakuan, masing-masing 5 ekor : kelompok 1, Kontrol Negatif (KN): tikus normal tanpa dilakukan torsio testis dan tanpa pemberian ekstrak tomat, kelompok 2, Kontrol Positif (KP): tikus dilakukan torsio testis unilateral 720o selama 6 jam setelah detorsi tanpa diberi ekstrak tomat, kelompok 3, perlakuan 1 (P1) tikus dilakukan torsio testis unilateral 720o selama 6 jam setelah detorsi diberi ekstrak tomat dosis 100 mg/kg bb dan kelompok 4, perlakuan 2 (P2) tikus dilakukan torsio testis unilateral unilataral 720o selama 6 jam setelah detorsi diberi 200 mg/kg bb . Pemberian ekstrak tomat dilakukan secara oral selama 30 hari. Pengamatan patologi anatomi dilakukan dengan cara pengukuran panjang dan lebar testis, volume testis dan berat testis. Data yang diperoleh dianalisis dengan Anova uji lanjutan dengan uji Duncan. Hasil penelitian menunjukan pemberian ekstrak tomat berpengaruh terhadap perubahan patologi anatomi meliputi warna, bentuk, dan morfometri testis kontralateral. Pemberian ekstrak tomat 200mg/kg bb/ hari menghasilkan perubahan patologi anatomi lebih baik dibandingkan dengan ekstrak tomat dosis 100mg/kg bb/ hari. Kesimpulan pemberian ekstrak tomat dapat mempengaruhi perubahan patologi anatomi testis kontralateral setelah detorsi pada tikus putih yang mengalami torsio unilateral 720o selama 6 jam.

Kata kunci; Tikus Putih, Torsio Testis Unilateral, Patologi Anatomi Testis Kontralateral.

ABSTRACT This study aims to determine the effect of the tomato (Lycopersicum esculentum L.) anatomical pathology of the testes of white rats (Rattus novergicus) experiencing 720o unilateral torsion for 6 hours. A total of 20 white mice (Rattus novergicus) Wistar strain, male, 3-4 months old weighing 180-200 grams, were randomly divided into 4 treatment groups, 5 each: group 1, negative control (KN) : normal mice without testicular torsion and without tomato extract administration, group 2, Positive Control (KP): mice were subjected to 720o unilateral testicular torsion for 6 hours after detortion without being given tomato extract, group 3, treatment 1 (P1) rats were subjected to testicular torsion unilateral 720o for 6 hours after the detortion was given a dose of tomato extract 100 mg / kg bw and group 4, treatment 2 (P2) rats were subjected to unilateral unilateral torque 720o for 6 hours after the detortion was given 200 mg / kg bw. Tomato extract was administered orally for 30 days. Observation of anatomical pathology was carried out by measuring the length and width of the testes, testicular volume and testicular weight. The data obtained were analyzed by using the Anova further test with the Duncan test. The results showed that the administration of tomato extract had an effect on changes in anatomical pathology including shape and morphometry of the contralateral testis. The administration of tomato extract 200mg / kg bw / day resulted in better anatomic pathological changes than the tomato extract at the dose of 100mg / kg bw / day. The conclusion is that administration of tomato extract can influence the pathological changes of the contralateral testis anatomy after detortion in white rats with unilateral 720o torsion for 6 hours. Keywords: White Mice, Unilateral testes torsion, Anatomy pathology contralateral testes