Electronic Theses and Dissertation

Daun randu (Ceiba pentandra L. Gaertn.) merupakan merupakan salah satu bagian tumbuhan randu yang dapat merangsang pertumbuhan rambut dan berpotensi dikembangkan menjadi bentuk sediaan gel. Penelitian formulasi sediaan gel dari ekstrak daun randu telah dilakukan dengan tujuan membuat formulasi gel penumbuh rambut ekstrak etanol 70% daun randu menggunakan gelling agent Karbopol 934 dan menentukan konsentrasi optimum gelling agent Karbopol 934. Ekstrak etanol 70% diperoleh dengan metode maserasi, memiliki karakteristik berupa ekstrak kental berwarna coklat. Sediaan di formulasikan ke dalam 4 formulasi dengan variasi konsentrasi Karbopol 934 yaitu F1 (Karbopol 0,5%), F2 (Karbopol 0,75%), F3 (Karbopol 0,85%) dan F4 (Karbopol 1%). Keempat formulasi dilakukan evaluasi meliputi uji stabilitas (organoleptis, pH, daya sebar, daya lekat, dan viskositas) dengan metode cycling test, kemudian dilakukan uji iritasi dan uji hedonik. Hasil pengujian stabilitas menunjukkan karakteristik organoleptis dan homogenitas yang tidak mengalami perubahan. Hasil pengujian pH menunjukkan perubahan tetapi masih dalam rentang persyaratan. Hasil pengujian viskositas sediaan pada F1 dan F2 mengalami penurunan nilai viskositas dibawah normal. Sediaan F3 dan F4 memenuhi semua persyaratan evaluasi. Hasil pengujian iritasi menunjukkan semua formula tidak menyebabkan iritasi. Namun demikian formula F3 lebih disukai dibandingkan sediaan yang lain. Berdasarkan keseluruhan hasil evaluasi formula F3 merupakan formulasi dengan hasil evaluasi terbaik.

Kata kunci: ekstrak etanol 70% daun randu, gel, Karbopol 934

Randu leaves (Ceiba pentandra L. Gaertn.) is one part of the randu plant that can stimulate hair growth and has the potential to be developed into a gel dosage form. Research on the formulation of gel preparations from randu leaf extract has been carried out to make hair growth gel formulations of 70% ethanol extract of randu leaves using the gelling agent Carbopol 934 and determining the optimum concentration of gelling agent Carbopol 934. 70% ethanol extract obtained by the maceration method, has the characteristics of an extract thick brown. The preparations were formulated into 4 formulations with variations in the concentration of Carbopol 934, namely F1 (Carbopol 0.5%), F2 (Carbopol 0.75%), F3 (Carbopol 0.85%) and F4 (Carbopol 1%). The four formulations were evaluated including stability tests (organoleptic, pH, spreadability, adhesion, and viscosity) using the method cycling test, then irritation and hedonic tests were carried out. The results of the stability test showed that the organoleptic characteristics and homogeneity did not change. The pH test results showed changes but were still within the range of requirements. The results of testing the viscosity of the preparations on F1 and F2 decreased the viscosity value below normal. Preparations F3 and F4 met all evaluation requirements. The results of the irritation test showed that all formulas did not irritate. However, the F3 formula is preferred over other preparations. Based on the overall evaluation results, the F3 formula is the formulation with the best evaluation results. Keywords: 70% ethanol extract of randu leaves, gel, Carbopol 934