Electronic Theses and Dissertation

ABSTRAK
Pendahuluan: Carpal tunnel syndrome merupakan neuropati kompresi yang
mengenai saraf median, menyebabkan rasa nyeri, baal, dan kesemutan pada tangan,
yang dapat menurunkan kualitas hidup. Citicoline berperan dalam regenerasi saraf
setelah cedera sehingga mencegah terbentuknya neuroma yang dapat menginduksi
nyeri neuropatik. Penelitian ini untuk mengetahui efikasi kombinasi citicoline,
prednisolon dan gabapentin pada Carpal tunnel syndrome dalam mengurangi nyeri
neuropatik dan memperbaiki kecepatan hantar saraf.
Metode: Penelitian quasi experimental dengan rancangan non equivalent control
group design dan single blind. Penelitian mulai 1 Januari sampai 31 Maret 2021
dengan teknik consecutive sampling. Sampel terdiri dari dua kelompok yaitu:
kelompok I yang diberikan prednisolon, gabapentin serta citicoline, dan kelompok
II yang diberikan prednisolon, gabapentin dan plasebo. Dinilai skor Numeric Rating
Scale dan kecepatan hantar saraf.
Hasil: Perbaikan yang signifikan terlihat pada skor NRS (p-value = 0,019) dan
SNAP KHS kiri (p-value = 0,039) pada kelompok yang diberikan citicoline.
Kesimpulan: Kombinasi citicoline, prednisolon dan gabapentin memiliki efikasi
dalam tatalaksana Carpal tunnel syndrome dalam menurunkan skor nyeri dan
memperbaiki kecepatan hantar saraf.
Kata kunci: Carpal tunnel syndrome, Numeric rating scale, Kecepatan hantar saraf

ABSTRACT
Introduction: Carpal tunnel syndrome is a compression neuropathy that affects the
median nerve in the carpal tunnel causing pain, numbness, and tingling in the
hands, which can reduce quality of life. Citicoline plays a role in nerve regeneration
after injury to prevent the formation of neuromas that can induce neuropathic pain.
This study was conducted to determine the efficacy of combination of citicoline,
prednisolone and gabapentin in Carpal tunnel syndrome in reducing neuropathic
pain and improving nerve conduction velocity.
Methods: A quasi-experimental study with a non-equivalent control group design
and single blind. The study started from January 1 to March 31, 2021 with
consecutive sampling technique. The sample consisted of two groups: group I which
was given prednisolone, gabapentin and citicoline, and group II which was given
prednisolone, gabapentin and placebo. We assessed the numeric rating scale score
and nerve conduction velocity.
Results: Significant improvement was seen in the numeric rating scale score (pvalue

= 0.019), and the left of NCV SNAP (p-value = 0.039) in the citicoline
administered group.
Conclusion: The combination of citicoline, prednisolone and gabapentin has
efficacy in the treatment of carpal tunnel syndrome in reducing pain score and
improving nerve conduction velocity.
Keywords: Carpal tunnel syndrome, Numeric rating scale, Nerve conduction
velocity

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