Electronic Theses and Dissertation

Periodontitis adalah proses inflamasi yang terjadi pada gingiva, ligamen periodontal,
sementum, dan tulang alveolar. Sediaan gel Lidah buaya (Aloe vera) mengandung
saponin, flavonoid, fenol, tanin, alkaloid, dan steroid. Tanaman Lidah buaya juga
mengandung acemannan, aloe emodin, vitamin (B1, B2, B6, B12, dan C) dan sejumlah
mineral seperti kalsium, klorin, kromium, tembaga, besi, magnesium, mangan, kalium,
fosfor, natrium, dan seng. Penelitian ini bertujuan untuk mengetahui pengaruh sediaan
gel Lidah buaya terhadap tulang alveolar secara radiografi dan struktur mikroskopis
tulang alveolar tikus Wistar yang diinduksi periodontitis. Induksi periodontitis
dilakukan selama 14 hari dengan pemasangan wire ligature 0,008 inci pada area
servikal molar satu maksila. Jenis penelitian ini adalah eksperimental laboratoris secara
in vivo dibagi menjadi empat kelompok yaitu kelompok observasi, kelompok kontrol
negatif (pemberiaan basis gel), kelompok kontrol positif (pemberian gel
metronidazole), dan kelompok perlakuan (pemberian sediaan gel Lidah buaya).
Perawatan dilakukan dengan mengaplikasikan, basis gel, gel metronidazole, sediaan
gel Lidah buaya di pagi dan sore hari selama 14 hari. Hasil analisis one way ANOVA
menunjukkan adanya perbedaan yang bermakna terhadap kepadatan tulang alveolar
dengan p=0,000 (p=

Periodontitis is an inflammatory process that occurs in the gingiva, periodontal ligament, cementum, and alveolar bone. Aloe vera gel preparations contain saponins, flavonoids, phenols, tannins, alkaloids, and steroids. The Aloe vera plant also contains acemannan, aloe emodin, vitamins (B1, B2, B6, B12, and C), and several minerals such as calcium, chlorine, chromium, copper, iron, magnesium, manganese, potassium, phosphorus, sodium, and zinc. This study aims to determine the effect of Aloe vera gel preparations on the alveolar bone radiographically and the microscopic structure of the alveolar bone of Wistar rats induced by periodontitis. Periodontitis induction was carried out for 14 days with the installation of a 0.008-inch wire ligature in the cervical area of the maxillary first molar. This type of research is an in vivo laboratory experiment divided into four groups: the observation group, the negative control group (administration of gel base), the positive control group (administration of metronidazole gel), and the treatment group (administration of Aloe vera gel). Treatment is carried out by applying gel base, metronidazole gel, and Aloe vera gel preparation in the morning and evening for 14 days. The results of one-way ANOVA analysis showed that there was a significant difference in alveolar bone density with p p=0.000 (p=