Electronic Theses and Dissertation

Pendahuluan: Pencegahan terkait tingginya AKI sangat ditentukan oleh deteksi dini penyakit preeklampsia. Pengetahuan mengenai serum biomarker yang tepat dalam menentukan tingkat keparahan preeklampsia memegang peranan penting dalam menurunkan morbiditas dan mortalitas yang disebabkan oleh preeklampsia.

Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan HsCRP, fibrinogen dan asam urat dengan preeklampsia di Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh

Metode: Penelitian deskriptif-analitik dengan rancangan case control. Penelitian ini dilakukan di Kamar Bersalin dan Ruang rawat inap Rumah Sakit Umum Daerah dr. Zainoel Abidin Banda Aceh dari tanggal 1 April 2020 sampai 30 Juni 2020. Sampel penelitian ini adalah wanita dengan usia kehamilan 28-40 minggu yang normal dan yang menderita preeklampsia. Analisis bivariat digunakan untuk mencari hubungan atau korelasi antara variabel terikat dan bebas. Dalam analisis bivariat akan dilakukan pengujian statistik dengan uji t-test. Kriteria hubungan ditetapkan berdasarkan p-value (probabilitas) pada onfidence Interval (CI) 95% dan α = 0,05.

Hasil: Rerata IMT pada kelompok hamil normal rerata (mean) 26.61±2.65 dan pada kelompok preeklampsia usia ibu rerata 29.61±4.51. Berdasarkan usia ibu pada kelompok hamil normal rerata (mean) 31.67±4.58 dan pada kelompok preeklampsia usia ibu rerata 31.90±4.89. Rerata tekanan darah sistolik dan diastolik pasien preeklampsia secara berurutan adalah 170 mmHg dan 100 mmHg. Terdapat perbedaan kadar HsCRP (p-value = 0,000), fibrinogen (p-value = 0,000), dan asam urat (p-value = 0,000) antara ibu hamil normal dan preeklampsia. Ibu dengan preeklampsia memiliki kadar HsCRP sebesar 13,713 ± 4.322, fibrinogen sebesar 469,68 ± 75,251, dan asam urat sebesar 6,890 ± 1,502 yang lebih tinggi dari hamil normal.

Kesimpulan: Terdapat perbedaan antara kadar HsCRP, fibrinogen dan asam urat pada ibu hamil dengan preeklampsia dan hamil normal, dimana kadar ketiganya meningkat pada ibu dengan preeklampsia.

Kata Kunci: Asam Urat, Fibrinogen, High sensitivity C-Reactive Protein, Preeklampsia

Introduction: Prevention of high MMR is largely determined by early detection of preeclampsia. Knowledge of appropriate serum biomarkers in determining the severity of preeclampsia plays an important role in reducing morbidity and mortality caused by preeclampsia. Objective: This study aims to determine the correlation between HsCRP, fibrinogen and uric acid with preeclampsia at the Regional General Hospital dr. Zainoel Abidin Banda Aceh Methods: Descriptive-analytical research with case control design. This research was conducted in the maternity ward and inpatient ward of the dr. Zainoel Abidin Banda Aceh from April 1, 2020 to June 30, 2020. The sample of this study was women with normal 28-40 weeks of gestation and suffering from preeclampsia. Bivariate analysis was used to find the relationship or correlation between the dependent and independent variables. In the bivariate analysis, statistical testing will be carried out using the t-test. Relationship criteria were determined based on p-value (probability) at 95% confidence interval (CI) and = 0.05 Results: The mean BMI in the normal pregnant group (mean) was 26.61±2.65 and in the preeclampsia group the average maternal age was 29.61±4.51. Based on maternal age in the normal pregnant group the average (mean) was 31.67±4.58 and in the preeclampsia group the average maternal age was 31.90±4.89. The mean systolic and diastolic blood pressure of preeclampsia patients were 170 mmHg and 100 mmHg, respectively. There were differences in the levels of HsCRP (p-value = 0.000), fibrinogen (p-value = 0.000), and uric acid (p-value = 0.000) between normal pregnant women and preeclampsia. Mothers with preeclampsia had HsCRP levels of 13,713 ± 4,322, fibrinogen of 469,68 ± 75,251, and uric acid levels of 6,890 ± 1,502 which were higher than normal pregnancies. Conclusion: There is a difference between the levels of HsCRP, fibrinogen and uric acid in pregnant women with preeclampsia and normal pregnant women, where the levels of all three increase in women with preeclampsia. Keywords: Fibrinogen, High sensitivity C-Reactive Protein, Uric Acid, Severe Preeclampsia