Electronic Theses and Dissertation

EFEKTIVITAS EKSTRAK ETANOL UMBI TUMBUHAN SARANG SEMUT (Hydnophytum formicarum) TERHADAP PERUBAHAN
BOBOT BADAN TIKUS PUTIH JANTAN
DIABETES MELITUS




ABSTRAK


Diabetes melitus disebabkan oleh gangguan metabolisme yang terjadi pada pankreas. Penderita diabetes melitus untuk bertahan hidup sel menggunakan energi dari lemak dan protein. Tujuan penelitian ini untuk mengevaluasi efektivitas pemberian ekstrak umbi tumbuhan sarang semut dalam mengontrol bobot badan tikus putih diabetes melitus. Penelitian ini menggunakan tikus putih jantan sejumlah 20 ekor yang dibagi menjadi 5 kelompok perlakuan, setiap kelompok terdiri dari 4 ekor. Kelompok perlakuan terdiri dari P1, P2, P3, P4, dan P5. Tikus diadaptasi selama 7 hari, setelah itu P1 diberi pakan standar selama 14 hari sedangkan P2, P3, P4 dan P5 diberikan pakan tinggi lemak. Kemudian pada hari ke 15 P2, P3, P4, dan P5 disuntik aloksan secara intraperitoneal. Pada hari ke 22 tikus ditimbang bobot badannya. Setelah itu P3 diberikan terapi metformin 50 mg/kg bb, P4 diterapi Sarang semut 100 mg/kg bb, dan P5 diterapi sarang semut 200 mg/kg bb selama 14 hari. Pada hari ke 36 ditimbang bobot badan akhir tikus. Data dari penelitian ini diolah dengan uji statistik one way ANOVA dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bobot badan sebelum perlakuan tidak berbeda nyata (P

EFFECTIVENESS OF Hydnophytum formicarum TUBERS ETANOL EXTRACT ON BODY WEIGHT CHANGES IN MALE WHITE RATS WITH DIABETES MELLITUS ABSTRACT Diabetes mellitus is caused by metabolic disorders that occur in the pancreas. Patients with diabetes mellitus to survive cells use energy from fat and protein. The objective of this research study was to evaluate the effectiveness of using extracts from Hydnophytum formicarum in controlling the body weight of diabetic white rats. The study involved 20 male white rats, which were divided into five treatment groups consisting of four rats each. The treatment groups included P1, P2, P3, P4 and P5. The rats were acclimatized for seven days and then given a standard diet for 14 days, except for the positive control and therapy groups, which were given a high-fat diet. Then on day 15 the positive control and therapy groups were injected with alloxan intraperitoneally. On day 22, the rats' body weight was measured. After that, the P3 group received metformin therapy (50 mg/kg body weight), and P4 and P5 groups received H. formicarum 100 mg/kg body weight, and 200 mg/kg body weight, respectively for 14 days. On day 36, the rats' body weight was measured again. The data were analyzed using one-way ANOVA and followed by the Duncan test. The results indicated that the body weight of rats before treatment did not differ significantly between treatments (P