Electronic Theses and Dissertation

Ulkus traumatik merupakan salah satu lesi mukosa mulut yang paling sering disebabkan oleh trauma. Sel inflamasi termasuk neutrofil dan makrofag memiliki peran dalam penyembuhan luka ulkus traumatik. Daun kari (Murraya koenigii L.) mengandung flavonoid, alkaloid, tanin dan saponin yang bersifat antiinflamasi, antibakteri, dan antioksidan. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian patch ekstrak daun kari (Murraya koenigii L.) terhadap jumlah neutrofil dan makrofag terhadap penyembuhan trauma ulkus pada mukosa mulut tikus Wistar. Tikus Wistar jantan dipilih dengan teknik purposive sampling dan dibagi menjadi 3 kelompok dengan, kontrol negatif, kontrol positif, dan kelompok patch ekstrak daun kari. Hasil analisis statistik dengan menggunakan uji oneway ANOVA menunjukkan bahwa patch ekstrak daun kari berpengaruh terhadap jumlah neutrofil hari ke-8 (p=0,000), jumlah makrofag hari ke-4 (p=0,001) dan ke-8 (p=0,000), dan peningkatan jumlah makrofag pada fase inflamasi dan fase proliferasi (p=0,039) pada ulkus traumatik mukosa oral tikus Wistar. Disimpulkan bahwa pemberian patch ekstrak daun kari berpengaruh terhadap jumlah neutrofil hari ke-8, jumlah makrofag hari ke-4 dan hari ke-8, dan perbedaan jumlah makrofag pada fase inflamasi dan fase proliferasi pada ulkus traumatik mukosa oral tikus Wistar.

Kata kunci: Patch ekstrak daun kari, neutrofil, makrofag, ulkus traumatik, mukosa oral.

ulcer is one of the most common oral mucosa lesions often caused by trauma. Inflammatory cells including neutrophil and macrophage have a role in traumatic ulcer wound healing. Curry leaves (Murraya koenigii L.) contains flavonoids, alkaloids, tannins and saponins which are anti-inflammatory, antibacterial, and antioxidant. The purpose of this study was to determine the Effect of curry leaf extract patch (Murraya koenigii L.) on the number of neutrophil and macrophage of Wistar rats. The rats were selected using purposive sampling technique and were divided into 3 groups, negative control, positive control, and curry leaf extract patch treatment group. The results of statistical analysis using oneway ANOVA test showed that the curry leaf extract patch had an effect on the number of neutrophils on the 8th day (p=0.000), the number of macrophages on the 4th (p=0.001) and the 8th day (p=0.000), and the difference in the number of macrophages in the inflammatory and proliferative phases (p=0.039) of traumatic ulcers on the oral mucosa of Wistar rats. It was concluded that the curry leaf extract patches had an affect on the number of neutrophils on the 8th day, the number of macrophages on the 4th and 8th day, and the difference in the number of macrophages in the inflammatory phase and the proliferative phase in traumatic ulcers of the oral mucosa of Wistar rats. Keywords: Curry leaf patch extract, neutrophils, macrophage traumatic ulcers, oral mucosa