Electronic Theses and Dissertation

Kata kunci : Daun Suweg, Amorphophallus campanulatus, Antidiabetes.
Penelitian tentang antidiabetes dengan pemberian ekstrak daun suweg (Amorphophallus campanulatus) telah dilakukan dengan tujuan untuk mengetahui aktivitas ekstrak daun suweg (Amorphophallus campanulatus) sebagai antidiabetes. Metode penelitian ini dilakukan dengan mengekstrak daun suweg menggunakan tiga pelarut yaitu etanol, etil asetat, dan n-heksan kemudian dilanjutkan dengan skrining fitokimia, aktivitas antioksidan dengan metode DPPH pada absorbansi λmaks 517 nm. Pengujian aktivitas antidiabetes terhadap mencit (Mus musculus) dilakukan dengan 5 kelompok perlakuan dan 5 kali pengulangan yaitu kelompok kontrol negatif tanpa perlakuan, kontrol positif menggunakan metformin dan perlakuan dosis ekstrak etil asetat daun suweg (90, 102, 120, 135, dan 150 mg/Kg bb). Hasil uji fitokimia daun suweg pada ekstrak etanol positif mengandung alkaloid dan polifenol, ekstrak etil asetat positif mengandung polifenol dan ekstrak n-heksan positif mengandung steroid. Nilai IC50 ekstrak etanol daun suweg 6,38 ppm dan vitamin C 5,58 ppm, sedangkan nilai IC50 ekstrak etil asetat daun suweg 5,88 ppm dan vitamin C 4, 96 ppm. Sehingga kedua ekstrak ini memiliki aktivitas antioksidan paling kuat (

Key words : Suweg leaf, Amorphophallus campanulatus, Antidiabetes. Research on antidiabetes by giving Suweg (Amorphophallus campanulatus) leaf extract has been carried out with the aim of knowing the activity of Suweg (Amorphophallus campanulatus) leaf extract as an antidiabetic. This research method was carried out by extracting suweg leaves using three solvents namely ethanol, ethyl acetate, and n-hexane then continued with phytochemical screening, antioxidant activity using the DPPH method at absorbance max 517 nm. Testing of antidiabetic activity on mice (Mus musculus) was carried out with 5 treatment groups and 5 repetitions, namely the negative control group without treatment, the positive control using metformin and the dose of ethyl acetate extract of suweg leaf extract (90, 102, 120, 135, and 150 mg/day). kg bb). The results of the phytochemical test of suweg leaves on the ethanol extract were positive for alkaloids and polyphenols, the ethyl acetate extract was positive for polyphenols and the n-hexane extract was positive for steroids. The IC50 value of ethanol extract of suweg leaf is 6.38 ppm and vitamin C is 5.58 ppm, while the IC50 value of ethyl acetate extract of suweg leaf is 5.88 ppm and vitamin C is 4.96 ppm. So that these two extracts have the strongest antioxidant activity (