Electronic Theses and Dissertation

ABSTRAK

Perubahan kadar enzim serum glutamic oxaloacetic transaminase (SGOT) serta serum glutamic pyruvic transaminase (SGPT) ialah salah satu indikator adanya gangguan pada hati. Penelitian ini bertujuan melihat perubahan kadar enzim SGOT serta SGPT selama kesembuhan defek humerus kelinci yang diimplan dengan hidroksiapatit (HAp) dan plasma kaya trombosit (PKT). Penelitian ini menggunakan enam ekor kelinci jantan dengan bobot badan 1,5-2 kg serta usia 8-9 bulan yang terbagi ke dalam 2 kelompok perlakuan. Kelompok I (K-I): hidroksiapatit (HAp) dan Kelompok II (K-II): penambahan plasma kaya trombosit (PKT) dan hidroksiapatit (HAp). Pengambilan darah melalui vena auricularis dilakukan pada hari ke 0 sebelum perlakuan, 15, 30, 60, dan 90 setelah perlakuan. Hasil penelitian menunjukkan kadar enzim SGOT dan SGPT mengalami fluktuasi setelah perlakuan dengan perbedaan tidak signifikan (P>0,05) diantara kelompok perlakuan dan waktu pengamatan. Perubahan kadar enzim SGOT dan SGPT terjadi pada beberapa hari di pengamatan pertama yang mengalami peningkatan dan kembali menurun pada beberapa hari terakhir pengamatan yang masih dalam kisaran normal, sehingga penerapan hidroksiapatit (HAp) serta penambahan plasma kaya trombosit (PKT) memiliki potensi sebagai salah satu alternatif dalam bidang medis khususnya untuk subtitusi tulang (bone graft).

Kata Kunci : SGOT, SGPT, hidroksiapatit (HAp), plasma kaya trombosit (PKT)

ABSTRACT The changes in the levels of the enzymes serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) is one indicator of liver disorders. This study aimed to determine the changes in the levels of SGOT and SGPT enzymes during the healing of humeral defects in rabbits implanted with hydroxyapatite (HAp) and platelet rich plasma (PRP). This study used 6 male rabbits with a body weight of 1.5-2 kg and ages 8-9 months which were divided into 2 treatment groups. Group I (K-I): hydroxyapatite (HAp) and Group II (K-II): addition of platelet rich plasma (PRP) and hydroxyapatite (HAp). Blood sampling through the auricular vein was carried out on days 0 before treatment, 15, 30, 60, and 90 after treatment. The results showed that the levels of SGOT and SGPT enzymes fluctuated after treatment with no significant difference (P>0.05) between the treatment groups and the time of observation. Changes in SGOT and SGPT enzyme levels occurred in the first few days of observation which increased and decreased again in the last few days of observation which were still within the normal range, so that the use of hydroxyapatite (HAp) and the addition of platelet-rich plasma (PRP) has potential as an alternative. in the medical field, especially for bone substitution (bone graft). Keywords : SGOT, SGPT, hydroxyapatite (HAp), platelet rich plasma (PRP)