Electronic Theses and Dissertation

Abstrak demam berdarah dengue (dbd) merupakan penyakit infeksi demam akut yang terbagi menjadi 4 derajat keparahan. peningkatan enzim transaminase serta hepatomegali merupakan tanda yang sering pada penderita dbd. hal ini memperkuat dugaan bahwa hati merupakan tempat replikasi virus yang utama. tujuan penelitian ini untuk mengetahui perbedaan kadar serum glutamic xaloacetic transaminase (sgot) dan serum glutamic piruvic transaminase (sgpt) pada pasien demam berdarah dengue derajat i dan ii. penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. data diperoleh dari rekam medis pasien dbd dewasa yang menjalani rawat inap di rsud dr. zainoel abidin banda aceh dengan menggunakan teknik purposive sampling yang di uji statistik menggunakan uji mann-whitney. selama penelitian berlangsung didapatkan sampel sebanyak 55 subjek, yang terdiri dari laki-laki 42 (76,4%), dan perempuan 13 (23,6%). kadar serum glutamic oxaloacetic transaminase (sgot) menunjukkan hasil p value 0,185 (? ? 0,05) sedangkan kadar serum glutamic piruvic transaminase (sgpt) menunjukkan hasil p value 0,036 (? < 0,05). disimpulkan bahwa tidak terdapat perbedaan yang signifikan pada kadar sgot, namun terdapat perbedaan yang signifikan kadar sgpt pada penderita dbd derajat i dan derajat ii di rsud zainoel abidin. kata kunci : dbd, sgot, sgpt abstract dengue hemorrhagic fever is an acute fever infection that classified in 4 different degrees. the raise of transaminase enzyme level and hepatomegaly are signs usually happened in patients with dhf. this event strongly suggests liver as a main site for viral replication. the purpose of this research was to understand the difference between serum glutamic oxaloacetic transaminase (sgot) levels and serum glutamic piruvic transaminase (sgpt) of patients with degrees i and ii dhf. this research uses observational analytic study with a cross sectional approach. data were obtained from medical records of adult dhf patients hospitalized in the rsud zainoel abidin banda aceh by using a purposive sampling technique which was tested statistically using the mann-whitney. a total of 55 samples consisting of 42 men (76.4%), and 13 women (23.6%) were gathered during this research. serum glutamic oxaloacetic transaminase (sgot) showed p value of 0.185 (? ? 0,05) while serum glutamic piruvic transaminase (sgpt) showed p value of 0,036 (? < 0,05). in conclusion there was no significant sgot levels difference, while it was found there was a significant sgpt levels difference in sgpt levels in dhf grade i and ii patients in rsud zainoel abidin keyword : dhf, sgot, sgpt