Electronic Theses and Dissertation

Probiotik dan tanaman herbal memiliki efek yang baik terhadap saluran pencernaan pada penderita dm. penelitian ini bertujuan untuk mengetahui pengaruh pemberian susu kambing fermentasi l. casei dan filtrat daun pandan terhadap penurunan kadar glukosa darah dan histopatologi pankreas. sebanyak 24 ekor tikus jantan dibagi menjadi 6 perlakuan dan 3 kali pengulangan, yaitu p0 (normal), p1 (stz 30 mg/kg bb/i.p), p2 (metformin dosis 60 mg/kg bb (p.o)), p3 (susu kambing terfermentasi dan filtrat daun pandan (2 ml/p.o)). p4 (susu kambing fermentasi (2 ml/p.o), p5 (filtrat pandan (2 ml/p.o), selama 14 hari. dilakukan pengukuran kadar glukosa darah dan organ pankreas tikus putih dikoleksi, dilakukan pewarnaan haematoksilin eosin (he). hasil penelitian pada kelompok p0, p1, p2, p3, p4, dan p5 menunjukkan adanya penurunan kadar glukosa darah. secara histopatologi diameter pulau langerhans tidak terdapat perbedaan yang signifikan (p>0,05) antara kelompok perlakuan dengan kelompok kontrol, hasil skoring pulau langehans tidak berbeda nyata antara kelompok kontrol dan perlakuan. kesimpulannya, pemberian kombinasi susu fermentasi dengan filtrat daun pandan berpengaruh terhadap kadar glukosa darah dan tidak berpengaruh terhadap histopatologi pankreas tikus. kata kunci: susu kambing fermentasi, pandanus amaryllifolius roxb. kadar glukosa darah, hitopatologi pankreas

Probiotics and herbal plants have a good effect on the digestive tract in DM sufferers. This study aims to determine the effect of administering L. casei fermented goat's milk and pandan leaf filtrate on reducing blood glucose levels and pancreatic histopathology. A total of 24 male rats were divided into 6 treatments and 3 repetitions, namely P0 (normal), P1 (STZ 30 mg/kg BW/i.p), P2 (metformin dose 60 mg/kg BW (p.o)), P3 (fermented goat's milk and pandan filtrate (2 ml/p.o)). P4 (fermented goat's milk (2 ml/p.o), P5 (pandan filtrate (2 ml/p.o), for 14 days. Blood glucose levels were measured and the pancreatic organs of white mice were collected, Haematoxylin eosin (HE) stained. The results of the study in groups P0, P1, P2, P3, P4, and P5 showed a decrease in blood glucose levels. Histopathologically, there was no significant difference (P>0.05) in the diameter of the islets of Langerhans between the treatment group and the control grou., The scoring results of the islets of Langerhans were not significantly different between the control and treatment groups. In conclusion, giving a combination of fermented milk with pandan leaf filtrate has an effect on blood glucose levels and has no effect on rat pancreatic histopathology. Keywords: fermented goat's milk, Pandanus amaryllifolius Roxb. blood glucose levels, pancreatic histopathology