Electronic Theses and Dissertation

Abstrak diabetes melitus merupakan penyakit metabolik dan tidak menular. diabetes melitus disebabkan karena terganggunya metabolisme glukosa sehingga terjadi kerusakan sel-sel β pankreas yang membuat berkurangnya produksi insulin. ekstrak daun kersen (muntingia calabura l.) merupakan tanaman obat herbal yang mampu menurunkan kadar gula darah akibat kerusakan sel β pulau langerhans pankreas. tujuan dilakukan penelitian ini adalah untuk mengetahui efektivitas ekstrak daun kersen dalam memperbaiki kerusakan sel-sel di pulau langerhans pankreas. penelitian ini menggunakan hewan coba sebanyak 12 ekor tikus putih, berjenis kelamin jantan, berat badan 150-200 g, berumur 2-3 bulan dengan 4 kelompok perlakuan. semua kelompok perlakuan diberikan 45 mg/kg bb streptozotocin diinduksi secara intraperitoneal. kelompok perlakuan diberi aquades (p1), metformin 4,5 mg/kg bb (p2), ekstrak daun kersen 10% (p3) dan 15% (p4) secara oral selama 21 hari. berdasarkan hasil uji anova menunjukkan pemberian perlakuan berpengaruh nyata (p

ABSTRACT Diabetes mellitus is a metabolic and non-communicable disease. Diabetes mellitus is caused by disruption of glucose metabolism resulting in damage to the cells β of pancreas, which causes reduced insulin production. Kersen leaf extract (Muntingia calabura L.) is an herbal medicinal plant that can reduce blood sugar levels due to damage to pancreatic Langerhans islet β cells. The purpose of this study was to determine the effectiveness of cherry leaf extract in repairing damage to cells in pancreatic islets of Langerhans. This study used experimental animals, as many as 12 white rats, male, body weight 150-200 g, aged 2-3 months, with 4 treatment groups. All treatment groups were given 45 mg/Kg BW induced streptozotocin intraperitoneally. The treatment group was given aquades (P1), metformin 4.5 mg/Kg BW (P2), cherry leaf extract 10% (P3) and 15% (P4) orally for 21 days. Based on the results of the ANOVA test, it showed that the treatment had a real effect (P